Competing endogenous RNAs in human astrocytes: crosstalk and interacting networks in response to lipotoxicity.

ABSTRACT: Neurodegenerative diseases (NDs) are characterized by a progressive deterioration of neuronal function, leading to motor and cognitive damage in patients. Astrocytes are essential for maintaining brain homeostasis, and their functional impairment is increasingly recognized as central to the etiology of various NDs. Such impairment can be induced by toxic insults with palmitic acid (PA), a common fatty acid, that disrupts autophagy, increases reactive oxygen species, and triggers inflammation. Although the effects of PA on astrocytes have been addressed, most aspects of the dynamics of this fatty acid remain unknown. Additionally, there is still no model that satisfactorily explains how astroglia goes from being neuroprotective to neurotoxic. Current incomplete knowledge needs to be improve

SUBMITTER: Gil-Jaramillo N 

PROVIDER: S-EPMC10679742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature