H influenzae LPS colocalization with Toll-like receptor 4 in eosinophilic esophagitis.

ABSTRACT:

Background

Patients with eosinophilic esophagitis (EoE) have a unique esophageal microbiome with increased presence of Haemophilus influenzae, but its role in the disease is unclear.

Objective

Microbiome-derived bacterial LPS activation of Toll-like receptors (TLR) is a potential mechanism for inducing inflammation in other chronic inflammatory diseases, but it has not been studied in EoE. Our aim was therefore to study microbiome-derived bacterial LPS activation of TLRs in EoE.

Methods

We studied 10 patients with active EoE, 9 patients with inactive EoE, and 10 control patients. Esophageal biopsy samples from the controls, patients with active EoE (>15 eosinophils/hpf), and patients with inactive EoE were immunostained for the presence of H influenzae L

SUBMITTER: Ravi A 

PROVIDER: S-EPMC10679775 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature