Health Economic Analysis of Antiviral Drugs in the Global Polio Eradication Endgame.

ABSTRACT:

Background

Polio antiviral drugs (PAVDs) may provide a critical tool in the eradication endgame by stopping poliovirus infections in immunodeficient individuals who may not clear the virus without therapeutic intervention. Although prolonged/chronic poliovirus excreters are rare, they represent a source of poliovirus reintroduction into the general population. Prior studies that assumed the successful cessation of all oral poliovirus vaccine (OPV) use estimated the potential upper bound of the incremental net benefits (INBs) of resource investments in research and development of PAVDs. However, delays in polio eradication, OPV cessation, and the development of PAVDs necessitate an updated economic analysis to reevaluate the costs and benefits of further investments in PAVDs.

Met

SUBMITTER: Badizadegan K 

PROVIDER: S-EPMC10680042 | biostudies-literature | 2023 Oct-Nov

REPOSITORIES: biostudies-literature