Implementation of a high sensitivity cardiac troponin I assay and risk of myocardial infarction or death at five years: observational analysis of a stepped wedge, cluster randomised controlled trial.

ABSTRACT:

Objective

To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients with suspected acute coronary syndrome.

Design

Secondary observational analysis of a stepped wedge, cluster randomised controlled trial.

Setting

10 secondary and tertiary care centres in Scotland, UK.

Participants

48 282 consecutive patients with suspected acute coronary syndrome. Myocardial injury was defined as any high sensitivity assay result for cardiac troponin I >99th centile of 16 ng/L in women and 34 ng/L in men.

Intervention

Hospital sites were randomly allocated to either early (n=5 hospitals) or late (n=5 hospitals) implementation of a high sensitivity cardiac troponin I assay with sex specific diagnostic threshol

SUBMITTER: Lee KK 

PROVIDER: S-EPMC10680066 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature