Comprehensive genomic profiling reveals prognostic signatures and insights into the molecular landscape of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a prevalent malignancy with diverse molecular characteristics. The NGS-based approach enhances our comprehension of genomic landscape of CRC and may guide future advancements in precision oncology for CRC patients.

Method

In this research, we conducted an analysis using Next-Generation Sequencing (NGS) on samples collected from 111 individuals who had been diagnosed with CRC. We identified somatic and germline mutations and structural variants across the tumor genomes through comprehensive genomic profiling. Furthermore, we investigated the landscape of driver mutations and their potential clinical implications.

Results

Our findings underscore the intricate heterogeneity of genetic alterations within CRC. Notably, BRAF,

SUBMITTER: Yang J 

PROVIDER: S-EPMC10680082 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature