Skeletal muscle adiposity is a novel risk factor for poor cognition in African Caribbean women.

ABSTRACT:

Objective

Skeletal muscle adiposity (myosteatosis) is recognized as a major risk factor for cardiometabolic diseases, and it increases with aging. The relationship of myosteatosis with cognitive impairment is unknown.

Methods

The association of calf myosteatosis (measured by computed tomography-derived skeletal muscle density; higher values indicate less myosteatosis) with cognitive function was examined among 626 African Caribbean women who were aged 40 to 84 years, a population highly vulnerable to increased myosteatosis. Cognition was assessed by the Digit Symbol Substitution Test (DSST), a test of information processing speed (higher scores indicate better performance). Linear regression was used to assess the association of muscle density with DSST.

Results

Adjus

SUBMITTER: Acevedo-Fontanez AI 

PROVIDER: S-EPMC10680092 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature