Photoredox Catalysis-Enabled Sulfination of Alcohols and Bromides.

ABSTRACT: Sulfinates are important lynchpin intermediates in pharmaceutical production; however, their synthesis via photoredox catalysis is challenging because of their facile oxidation. We herein disclose a photocatalytic strategy for the direct conversion of alcohols and alkyl bromides into alkyl sulfinates. These transformations are enabled by the utilization of easily oxidized radical precursors─namely, alcohol N-heterocyclic carbene adducts and N-adamantyl aminosupersilane─that facilitate efficient synthesis of the oxidatively labile sulfinate products. A broad range of functional groups are amenable to the reported transformations, providing rapid access to sulfonamides, sulfonyl halides, sulfones, and sulfonic acids. The utility of these methods is further demonstrated via the

SUBMITTER: Carson Ii WP 

PROVIDER: S-EPMC10680125 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature