Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is a lethal mammary carcinoma subtype that affects females and is associated with a worse prognosis. Chemotherapy is the only conventional therapy available for patients with TNBC due to the lack of therapeutic targets. Yttrium oxide (Y₂O₃) is a rare earth metal oxide, whose nanoparticle (NPs) formulations are used in various applications, including biological imaging, the material sciences, and the chemical synthesis of inorganic chemicals. However, the biological activity of Y₂O₃-NPs against TNBC cells has not been fully explored. The current study was conducted to assess Y₂O₃-NPs' anticancer activity against the human TNBC MDA-MB-231 cell line.

Methods

Transmi

SUBMITTER: Emad B 

PROVIDER: S-EPMC10680179 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature