Hypoxia-inducible factor 1α modulates interstitial pneumonia-mediated lung cancer progression.

ABSTRACT:

Background

The prognosis of patients with lung cancer accompanied by interstitial pneumonia is poorer than that of patients with lung cancer but without interstitial pneumonia. Moreover, the available therapeutic interventions for lung cancer patients with interstitial pneumonia are limited. Therefore, a new treatment strategy for these patients is required. The aim of the present study was to investigate the pathophysiological relationship between interstitial pneumonia and lung cancer and explore potential therapeutic agents.

Methods

A novel hybrid murine model of lung cancer with interstitial pneumonia was established via bleomycin-induced pulmonary fibrosis followed by orthotopic lung cancer cell transplantation into the lungs. Changes in tumor progression, lung fibrosis

SUBMITTER: Shimoji K 

PROVIDER: S-EPMC10680219 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature