Comprehensive exploration of the involvement of cuproptosis in tumorigenesis and progression of neuroblastoma.

ABSTRACT:

Background

Copper-induced cell death, or "cuproptosis," as an apoptotic process, has recently received much attention in human diseases. Recent studies on cuproptosis have provided novel insights into the pathogenesis of various diseases, especially cancers. However, the association between neuroblastoma (NB) and cuproptosis in terms of their clinical outcomes, tumorigenesis, and treatment response remains unclear.

Methods

To determine the role of cuproptosis in NB tumorigenesis and progression, this study employed a systematic technique to explore the characteristic patterns of 10 key cuproptosis-related genes (CUGs) in NB. Consensus clustering analysis of the TARGET and GEO databases divided the NB patients into two subgroups that showed different clinicopathological attri

SUBMITTER: Zhou R 

PROVIDER: S-EPMC10680286 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature