Exploring shared neural substrates underlying cognition and gait variability in adults without dementia.

ABSTRACT:

Background

High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia. The objective of this study was to identify cortical or subcortical structures of the brain shared by gait variability measured using a body-worn tri-axial accelerometer (TAA) and cognitive function.

Methods

This study is a part of a larger population-based cohort study on cognitive aging and dementia. The study included 207 participants without dementia, with a mean age of 72.6, and 45.4% of them are females. We conducted standardized diagnostic interview including a detailed medical history, physical and neurological examinations, and laboratory tests for cognitive impairment. We obtained gait variability during walking usi

SUBMITTER: Byun S 

PROVIDER: S-EPMC10680297 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature