ITRAQ-based proteomics analysis of human ectopic endometrial stromal cells treated by Maqian essential oil.

ABSTRACT:

Background

Endometriosis is a common and complex syndrome characterized by the presence of endometrial-like tissue outside the uterus. Chinese medicine has been recently found to show good efficacy in treating endometriosis. Our previous results revealed that Maqian fruit essential oil (MQEO) could inhibit the proliferation and induce apoptosis of ectopic endometrial stromal cells (EESCs), but the mechanisms remain unclear. In this study, we aim to explore the molecular mechanism of MQEO's specific effects in EESCs.

Methods

We conducted a quantitative proteomics analysis by iTRAQ on EESCs treated with MQEO or DMSO. Then deep analysis was performed based on differentially expressed proteins, including Gene Ontology enrichment analysis, pathway enrichment analysis and protein

SUBMITTER: Zhang LY 

PROVIDER: S-EPMC10680300 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature