Effects of sputum bacillary load and age on GeneXpert and traditional methods in pulmonary tuberculosis: a 4-year retrospective comparative study.

ABSTRACT:

Background

The purpose of this study was to evaluate the diagnostic value of the GeneXpert^® MTB/RIF (Xpert^®), Auramine O staining method, and Lowenstein-Jensen medium for bacteriologically confirmed pulmonary tuberculosis and explore the effects of the sputum bacillary load (SBL) and qRT‒PCR threshold cycle (Ct) value on the detection methods.

Methods

We retrospectively analysed the results in the Department of Infectious Disease for 49 months. The χ² test was used to compare the performances of each method, receiver operating characteristic curve analysis was used to determine the optimal cut-off values, and the factors associated with a false-negative result from Xpert^® were analysed by logistic regression.

Results

Simulta

SUBMITTER: Li K 

PROVIDER: S-EPMC10680317 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature