Role of surgery in T4N0-3M0 esophageal cancer.

ABSTRACT:

Background

This study aimed to investigate an unsettled issue that whether T4 esophageal cancer could benefit from surgery.

Methods

Patients with T4N0-3M0 esophageal cancer from 2004 to 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were included in this study. Kaplan-Meier method, Cox proportional hazard regression, and propensity score matching (PSM) were used to compare overall survival (OS) between the surgery and no-surgery group.

Results

A total of 1822 patients were analyzed. The multivariable Cox regression showed the HR (95% CI) for surgery vs. no surgery was 0.492 (0.427-0.567) (P < 0.001) in T4N0-3M0 cohort, 0.471 (0.354-0.627) (P < 0.001) in T4aN0-3M0 cohort, and 0.480 (0.335-0.689) (P < 0.001) in T4bN0-3M0 cohort. The HR (95% CI

SUBMITTER: Qi C 

PROVIDER: S-EPMC10680323 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature