Development of a 5-mRNAsi-related gene signature to predict the prognosis of colon adenocarcinoma.

ABSTRACT:

Aim

To create a prognosis model based on mRNA-based stem index (mRNAsi) for evaluating the prognostic outcomes of colon adenocarcinoma (COAD).

Background

Generation of heterogeneous COAD cells could be promoted by the self-renewal and differentiation potential of cancer stem cells (CSCs). Biomarkers contributing to the development of COAD stem cells remained to be discovered.

Objective

To develop and validate an mRNAsi-based risk model for estimating the prognostic outcomes of patients suffering from COAD.

Methods

Samples were collected from Rectal Adenocarcinoma (TCGA-READ) PanCancer Atlas datasets, The Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD), and the GSE87211 dataset. MRNAsi was calculated by one-class logistic regression (OCLR) algorithm. Under

SUBMITTER: Huang H 

PROVIDER: S-EPMC10680455 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature