Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors.

ABSTRACT: Human neutrophils respond to multiple chemoattractants to guide their migration from the vasculature to sites of infection and injury, where they clear pathogens and amplify inflammation. To properly focus their responses during this complex navigation, neutrophils prioritize pathogen- and injury-derived signals over long-range inflammatory signals, such as the leukotriene LTB4, secreted by host cells. Different chemoattractants can also drive qualitatively different modes of migration even though their receptors couple to the same Gα_i family of G proteins. Here, we used live-cell imaging to demonstrate that the responses differed in their signaling dynamics. Low-priority chemoattractants caused transient responses, whereas responses to high-priority chemoattractants were sustai

SUBMITTER: Lundgren SM 

PROVIDER: S-EPMC10680494 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature