The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration.

ABSTRACT: Increasing evidence shows that many human-targeted drugs alter the gut microbiome, leading to implications for host health. However, much less is known about the mechanisms by which drugs target the microbiome and how drugs affect microbial function. Here we combined quantitative microbiome profiling, long-read metagenomics, stable isotope probing and single-cell chemical imaging to investigate the impact of two widely prescribed nervous system-targeted drugs on the gut microbiome. Ex vivo supplementation of physiologically relevant concentrations of entacapone or loxapine succinate to faecal samples significantly impacted the abundance of up to one third of the microbial species present. Importantly, we demonstrate that the impact of these drugs on microbial metabolism is much more

SUBMITTER: Pereira FC 

PROVIDER: S-EPMC10680583 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature