SPREd: A simulation-supervised neural network tool for gene regulatory network reconstruction.

ABSTRACT: Reconstruction of gene regulatory networks (GRNs) from expression data is a significant open problem. Common approaches train a machine learning (ML) model to predict a gene's expression using transcription factors' (TFs') expression as features and designate important features/TFs as regulators of the gene. Here, we present an entirely different paradigm, where GRN edges are directly predicted by the ML model. The new approach, named "SPREd" is a simulation-supervised neural network for GRN inference. Its inputs comprise expression relationships (e.g., correlation, mutual information) between the target gene and each TF and between pairs of TFs. The output includes binary labels indicating whether each TF regulates the target gene. We train the neural network model using synthetic express

SUBMITTER: Wu Z 

PROVIDER: S-EPMC10680606 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature