Cell intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow.

ABSTRACT: Cytokinesis is the process where the mother cell's cytoplasm separates into daughter cells. This is driven by an actomyosin contractile ring that produces cortical contractility and drives cleavage furrow ingression, resulting in the formation of a thin intercellular bridge. While cytoskeletal reorganization during cytokinesis has been extensively studied, little is known about the spatiotemporal dynamics of the plasma membrane. Here, we image and model plasma membrane lipid and protein dynamics on the cell surface during leukemia cell cytokinesis. We reveal an extensive accumulation and folding of plasma membrane at the cleavage furrow and the intercellular bridge, accompanied by a depletion and unfolding of plasma membrane at the cell poles. These membrane dynamics are caused by two acto

SUBMITTER: Alonso-Matilla R 

PROVIDER: S-EPMC10680611 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature