Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice.

ABSTRACT: TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases, including frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Recently, TMEM106B polymorphisms have been associated with tauopathy in chronic traumatic encephalopathy (CTE) and FTLD-TDP patients. However, how TMEM106B influences Tau pathology and its associated neurodegeneration, is unclear. Here we show that loss of TMEM106B enhances the accumulation of pathological Tau, especially in the neuronal soma in the hippocampus, resulting in severe neuronal loss in the PS19 Tau transgenic mice. Moreover, Tmem106b^-/- PS19 mice develop significantly increased disruption of the

SUBMITTER: Feng T 

PROVIDER: S-EPMC10680640 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature