GCN2 mediates access to stored amino acids for somatic maintenance during Drosophila ageing.

ABSTRACT: Many mechanistic theories of ageing argue that a progressive failure of somatic maintenance, the use of energy and resources to prevent and repair damage to the cell, underpins ageing. To sustain somatic maintenance an organism must acquire dozens of essential nutrients from the diet, including essential amino acids (EAAs), which are physiologically limiting for many animals. In Drosophila, adulthood deprivation of each individual EAA yields vastly different lifespan trajectories, and adulthood deprivation of one EAA, phenylalanine (Phe), has no associated lifespan cost; this is despite each EAA being strictly required for growth and reproduction. Moreover, survival under any EAA deprivation depends entirely on the conserved AA sensor GCN2, a component of the integrated stress respo

SUBMITTER: Johnstone JN 

PROVIDER: S-EPMC10680771 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature