Regenerative Signatures in Bronchioalveolar Lavage of Acute Respiratory Distress Syndrome.

ABSTRACT:

Background

In patients with severe acute respiratory distress syndrome (ARDS) associated with sepsis, lung recovery is considerably delayed, and mortality is much high. More insight into the process of lung regeneration in ARDS patients is needed. Exosomes are important cargos for intercellular communication by serving as autocrine and/or paracrine. Cutting-edge exomics (exosomal proteomics) makes it possible to study the mechanisms of re-alveolarization in ARDS lungs.

Aims

This study aimed to identify potential regenerative niches by characterizing differentially expressed proteins in the exosomes of bronchioalveolar lavage (BAL) in ARDS patients.

Methods

We purified exosomes from BAL samples collected from ARDS patients by NIH-supported ALTA and SPIROMICS trials. Th

SUBMITTER: Zhao R 

PROVIDER: S-EPMC10680787 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature