High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia.

ABSTRACT: Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation to cause metabolic and chronic inflammatory diseases, and are also considered an environmental risk factor for gynecologic diseases. Here, we aimed to examine how HFD alter an inflammatory environment in endometriosis and discern their contribution to endometriotic-associated hyperalgesia. Our results showed that HFD-induced obesity enhanced abdominal mechanical allodynia that was induced by endometriotic lesions. Peritoneal inflammatory macrophages and cytokine levels increased by lesion induction were elevated by chronic exposure to HFD. Pain-related

SUBMITTER: Herup-Wheeler T 

PROVIDER: S-EPMC10680790 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature