Fast and accurate local ancestry inference with Recomb-Mix.

ABSTRACT: The availability of large genotyped cohorts brings new opportunities for revealing high-resolution genetic structure of admixed populations, via local ancestry inference (LAI), the process of identifying the ancestry of each segment of an individual haplotype. Though current methods achieve high accuracy in standard cases, LAI is still challenging when reference populations are more similar (e.g., intra-continental), when the number of reference populations is too numerous, or when the admixture events are deep in time, all of which are increasingly unavoidable in large biobanks. Here, we present a new LAI method, Recomb-Mix. Adopting the commonly used site-based formulation based on the classic Li and Stephens' model, Recomb-Mix integrates the elements of existing methods and introduces a

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10680832 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature