Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression.

ABSTRACT: Serous borderline tumors (SBT) are epithelial neoplastic lesions of the ovaries that commonly have a good prognosis. In 10-15% of cases, however, SBT will recur as low-grade serous cancer (LGSC), which is deeply invasive and responds poorly to current standard chemotherapy^1,2,3. While genetic alterations suggest a common origin, the transition from SBT to LGSC remains poorly understood⁴. Here, we integrate spatial proteomics⁵ with spatial transcriptomics to elucidate the evolution from SBT to LGSC and its corresponding metastasis at the molecular level in both the stroma and the tumor. We show that the transition of SBT to LGSC occurs in the epithelial compartment through an intermediary stage with micropapillary features (SBT-MP), which involves a gradual

SUBMITTER: Schweizer L 

PROVIDER: S-EPMC10680885 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature