Genomic Insights into the Shared and Distinct Genetic Architecture of Cognitive Function and Schizophrenia.

ABSTRACT: Cognitive impairment is a major determinant of functional outcomes in schizophrenia, and efforts to understand the biological basis of cognitive dysfunction in the disorder are ongoing. Previous studies have suggested genetic overlap between global cognitive ability and schizophrenia, but further work is needed to delineate the shared genetic architecture. Here, we apply genomic structural equation modelling to identify latent cognitive factors capturing genetic liabilities to 12 cognitive traits measured in the UK Biobank (UKB). We explore the overlap between latent cognitive factors, schizophrenia, and schizophrenia symptom dimensions using a complementary set of statistical approaches, applied to data from the latest schizophrenia genome-wide association study (Ncase = 53,386, Ncontrol

SUBMITTER: Wootton O 

PROVIDER: S-EPMC10680895 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature