Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton.

ABSTRACT: Complex behaviors are mediated by neural computations occurring throughout the brain. In recent years, tremendous progress has been made in developing technologies that can record neural activity at cellular resolution at multiple spatial and temporal scales. However, these technologies are primarily designed for studying the mammalian brain during head fixation - wherein the behavior of the animal is highly constrained. Miniaturized devices for studying neural activity in freely behaving animals are largely confined to recording from small brain regions owing to performance limitations. We present a cranial exoskeleton that assists mice in maneuvering neural recording headstages that are orders of magnitude larger and heavier than the mice, while they navigate physical behavioral environm

SUBMITTER: Hope J 

PROVIDER: S-EPMC10680923 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature