Assessing delayed penicillin hypersensitivity using the PENFAST+ score.

ABSTRACT:

Introduction

Approximately 10% of individuals report a suspected allergy to penicillin, but according to allergy work-ups, only 10%-15% of them are truly allergic. A clinical decision score, the PEN-FAST, was developed and validated to identify adults with low-risk penicillin allergy.

Objectives

The objective of this study was to improve the performance of the PEN-FAST score, particularly for those with delayed hypersensitivity (HS), by improving the negative predictive value.

Methods

STEP 1: Retrospective evaluation of the PEN-FAST score in patients with proven immediate and delayed penicillin allergy. STEP 2: Identification of additional criteria among Step 1 patients misclassified by PEN-FAST score. Development of the PEN-FAST+ score using multivariable logistic re

SUBMITTER: Castagna J 

PROVIDER: S-EPMC10680989 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature