Proteomics to Metabolomics: A New Insight into the Pathogenesis of Hypertensive Nephropathy.

ABSTRACT:

Background

Hypertensive nephropathy (HN) is a high-burden disorder and a leading cause of end-stage renal disease. Despite huge investigations, the underlying mechanisms are yet largely unknown. Systems biology is a promising approach to providing a comprehensive insight into this complex disorder.

Methods

Proteome profiles of kidney tubulointerstitium and outer and inner cortex from a rat model of HN were retrieved from the proteomics identification database, and the quality of the datasets was assessed. Proteins that exhibited differential expression were detected and their interactions were analyzed in the kidney sub-compartments. Furthermore, enzymes were linked to the attributed metabolites. Functional enrichment analyses were performed to identify key pathways and proc

SUBMITTER: Eshraghi Y 

PROVIDER: S-EPMC10681119 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature