Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines.

ABSTRACT: Liver fibrosis is the result of sustained chronic liver injury and inflammation leading to hepatocyte cell death followed by the formation of fibrous scars, which is the hallmark of NASH and alcoholic steatohepatitis and can lead to cirrhosis, HCC, and liver failure. Although progress has been made in understanding the pathogenesis and clinical consequences of hepatic fibrosis, therapeutic strategies for this disease are limited. Preclinical studies suggest that peroxisome proliferator-activated receptor alpha plays an important role in preventing the development of liver fibrosis by activating genes involved in detoxifying lipotoxicity and toxins, transrepressing genes involved in inflammation, and inhibiting activation of hepatic stellate cells. Given the robust preclinical data, several

SUBMITTER: Gong L 

PROVIDER: S-EPMC10681123 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature