The causal relationship between pure hypercholesterolemia and psoriasis: A bidirectional, two-sample Mendelian randomization study.

ABSTRACT:

Background

Several studies have reported the association between pure hypercholesterolemia (PH) and psoriasis, but the causal effect remains unclear.

Methods

We explored the causal effect between PH and psoriasis using two-sample bidirectional Mendelian randomization (MR) analysis using data from genome-wide association studies. Single nucleotide polymorphisms related with exposures at the genome-wide significance level (p < 5×10^-8 ) and less than the linkage disequilibrium level (r²  < 0.001) were chosen as instrumental variables. Subsequently, we used inverse variance weighting (IVW), MR-Egger and weighted median (WM) methods for causal inference. p < 0.05 was considered statistically significant. Heterogeneity was tested using Cochran's Q-test, and h

SUBMITTER: Bai R 

PROVIDER: S-EPMC10681133 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature