Role of the volume conductor on simulations of local field potential recordings from deep brain stimulation electrodes.

ABSTRACT:

Objective

Local field potential (LFP) recordings from deep brain stimulation (DBS) electrodes are commonly used in research analyses, and are beginning to be used in clinical practice. Computational models of DBS LFPs provide tools for investigating the biophysics and neural synchronization that underlie LFP signals. However, technical standards for DBS LFP model parameterization remain to be established. Therefore, the goal of this study was to evaluate the role of the volume conductor (VC) model complexity on simulated LFP signals in the subthalamic nucleus (STN).

Approach

We created a detailed human head VC model that explicitly represented the inhomogeneity and anisotropy associated with 12 different tissue structures. This VC model represented our "gold standard" for te

SUBMITTER: Noor MS 

PROVIDER: S-EPMC10681243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature