Type of anesthesia for cancer resection surgery: No differential impact on cancer recurrence in mouse models of breast cancer.

ABSTRACT:

Background

Surgery is essential for curative treatment of solid tumors. Evidence from recent retrospective clinical analyses suggests that use of propofol-based total intravenous anesthesia during cancer resection surgery is associated with improved overall survival compared to inhaled volatile anesthesia. Evaluating these findings in prospective clinical studies is required to inform definitive clinical guidelines but will take many years and requires biomarkers to monitor treatment effect. Therefore, we examined the effect of different anesthetic agents on cancer recurrence in mouse models of breast cancer with the overarching goal of evaluating plausible mechanisms that could be used as biomarkers of treatment response.

Methods

To test the hypothesis that volatile anesthe

SUBMITTER: Dubowitz J 

PROVIDER: S-EPMC10681249 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature