External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration.

ABSTRACT: Sprouting angiogenesis plays a key role during bone regeneration. For example, insufficient early revascularization of the injured site can lead to delayed or non-healing. During sprouting, endothelial cells are known to be mechano-sensitive and respond to local mechanical stimuli. Endothelial cells interact and communicate mechanically with their surroundings, such as outer-vascular stromal cells, through cell-induced traction forces. In addition, external physiological loads act at the healing site, resulting in tissue deformations and impacting cellular arrangements. How these two distinct mechanical cues (cell-induced and external) impact angiogenesis and sprout patterning in early bone healing remains however largely unknown. Therefore, the aim of this study was to investigate the rel

SUBMITTER: Dazzi C 

PROVIDER: S-EPMC10681321 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature