Rate of Pathogenic Germline Variants in Patients With Lung Cancer.

ABSTRACT:

Purpose

Germline genetic testing (GGT) is now recommended for all patients diagnosed with ovarian or pancreatic cancer and for a large proportion of patients based solely on a diagnosis of colorectal or breast cancer. However, GGT is not yet recommended for all patients diagnosed with lung cancer (LC), primarily because of a lack of evidence that supports a significant frequency of identifying pathogenic germline variants (PGVs) in these patients. This study characterizes GGT results in a cohort of patients with LC.

Methods

We reviewed deidentified data for 7,788 patients with GGT (2015-2022). PGV frequencies were compared to a control cohort of unaffected individuals. GGT results were stratified by genomic ancestry, history of cancer, and PGV clinical actionability per curr

SUBMITTER: Sorscher S 

PROVIDER: S-EPMC10681406 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature