Severe necrotizing soft tissue infections-Is wound microbiology a prognostic factor for clinical outcome?

ABSTRACT: Necrotizing soft tissue infections (NSTIs) represent similar pathophysiological features, but the clinical course might range from subacute to a rapidly progressive, fulminant sepsis. Initial wound microbiology is the base for the Guiliano classification. The timeline of microbiological colonization has not been described during the clinical course. The role of the different microbiological pathogens on the outcome and mortality is unclear. One hundred eighty patients were included with septic inflammation response syndrome on admission. Initial wound microbiology and the changes in wound microbiology were analysed during the clinical course and correlated with outcome and risk indicators. Overall mortality was 35%. Higher age, a high Charlson Comorbidity Index or ASA score and truncal inf

SUBMITTER: Friederichs J 

PROVIDER: S-EPMC10681420 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature