Building an adaptive dose simulation framework to aid dose and schedule selection.

ABSTRACT: Establishing a dosing regimen that maximizes clinical benefit and minimizes adverse effects for novel therapeutics is a key objective for drug developers. Finding an optimal dose and schedule can be particularly challenging for compounds with a narrow therapeutic window such as in oncology. Modeling and simulation tools can be valuable to conduct in silico evaluations of various dosing scenarios with the goal to identify those that could minimize toxicities, avoid unscheduled dose interruptions, or minimize premature discontinuations, which all could limit the potential for therapeutic benefit. In this tutorial, we present a stepwise development of an adaptive dose simulation framework that can be used for dose optimization simulations. The tutorial first describes the general workflow, fo

SUBMITTER: Hooijmaijers R 

PROVIDER: S-EPMC10681481 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature