Central nervous system Aspergillus quadrilineatus infection in a COVID-19 patient, a case report and literature review.

ABSTRACT:

Background

Viral pneumonia such as COVID-19-associated aspergillosis could increase susceptibility to fungal super-infections in critically ill patients.

Methods

Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID-19-positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species.

Results

Histopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure. The species-level identity of isolate growing on brain biopsy culture was confirmed by PCR sequencing of the β-tubulin gene as A. quadrilineatus. Using the CLSI M38-A3 broth micro

SUBMITTER: Amirizad K 

PROVIDER: S-EPMC10681513 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature