Ontology highlight
ABSTRACT:
SUBMITTER: Gevertz JL
PROVIDER: S-EPMC10681518 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Gevertz Jana L JL Kareva Irina I
CPT: pharmacometrics & systems pharmacology 20230706 11
Despite the growing appreciation that the future of cancer treatment lies in combination therapies, finding the right drugs to combine and the optimal way to combine them remains a nontrivial task. Herein, we introduce the Multi-Objective Optimization of Combination Synergy - Dose Selection (MOOCS-DS) method for using drug synergy as a tool for guiding dose selection for a combination of preselected compounds. This method decouples synergy of potency (SoP) and synergy of efficacy (SoE) and ident ...[more]