Revisiting deficits in threat and safety appraisal in obsessive-compulsive disorder.

ABSTRACT: Current behavioural treatment of obsessive-compulsive disorder (OCD) is informed by fear conditioning and involves iteratively re-evaluating previously threatening stimuli as safe. However, there is limited research investigating the neurobiological response to conditioning and reversal of threatening stimuli in individuals with OCD. A clinical sample of individuals with OCD (N = 45) and matched healthy controls (N = 45) underwent functional magnetic resonance imaging. While in the scanner, participants completed a well-validated fear reversal task and a resting-state scan. We found no evidence for group differences in task-evoked brain activation or functional connectivity in OCD. Multivariate analyses encompassing all participants in the clinical and control groups suggested that subject

SUBMITTER: Hearne LJ 

PROVIDER: S-EPMC10681637 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature