Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex.

ABSTRACT: Prolonged sensory deprivation has repeatedly been linked to cortical reorganization. We recently demonstrated that individuals with congenital anosmia (CA, complete olfactory deprivation since birth) have seemingly normal morphology in piriform (olfactory) cortex despite profound morphological deviations in the orbitofrontal cortex (OFC), a finding contradictory to both the known effects of blindness on visual cortex and to the sparse literature on brain morphology in anosmia. To establish whether these unexpected findings reflect the true brain morphology in CA, we first performed a direct replication of our previous study to determine if lack of results was due to a deviant control group, a confound in cross sectional studies. Individuals with CA (n = 30) were compared to age and sex mat

SUBMITTER: Peter MG 

PROVIDER: S-EPMC10681638 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature