Test-retest reliability and predictive utility of a macroscale principal functional connectivity gradient.

ABSTRACT: Mapping individual differences in brain function has been hampered by poor reliability as well as limited interpretability. Leveraging patterns of brain-wide functional connectivity (FC) offers some promise in this endeavor. In particular, a macroscale principal FC gradient that recapitulates a hierarchical organization spanning molecular, cellular, and circuit level features along a sensory-to-association cortical axis has emerged as both a parsimonious and interpretable measure of individual differences in behavior. However, the measurement reliabilities of this FC gradient have not been fully evaluated. Here, we assess the reliabilities of both global and regional principal FC gradient measures using test-retest data from the young adult Human Connectome Project (HCP-YA) and the Dunedin

SUBMITTER: Knodt AR 

PROVIDER: S-EPMC10681655 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature