Locus coeruleus activity improves cochlear implant performance.

ABSTRACT: Cochlear implants (CIs) are neuroprosthetic devices that can provide hearing to deaf people¹. Despite the benefits offered by CIs, the time taken for hearing to be restored and perceptual accuracy after long-term CI use remain highly variable^2,3. CI use is believed to require neuroplasticity in the central auditory system, and differential engagement of neuroplastic mechanisms might contribute to the variability in outcomes^4-7. Despite extensive studies on how CIs activate the auditory system^4,8-12, the understanding of CI-related neuroplasticity remains limited. One potent factor enabling plasticity is the neuromodulator noradrenaline from the brainstem locus coeruleus (LC). Here we examine behavioural responses and neural activity in LC and aud

SUBMITTER: Glennon E 

PROVIDER: S-EPMC10681749 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature