RegioneReloaded: evaluating the association of multiple genomic region sets.

ABSTRACT:

Motivation

Next-generation sequencing methods continue improving the annotation of genomes in part by determining the distribution of features such as epigenetic marks. Evaluating and interpreting the association between genomic regions and their features has become a common and challenging analysis in genomic and epigenomic studies.

Results

With regioneR we provided an R package allowing to assess the statistical significance of pairwise associations between genomic region sets using permutation tests. We now present the R package regioneReloaded that builds upon regioneR's statistical foundation and extends the functionality for the simultaneous analysis and visualization of the associations between multiple genomic region sets. Thus, we provide a novel discovery tool for

SUBMITTER: Malinverni R 

PROVIDER: S-EPMC10681856 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature