Tuberculin responses after BCG vaccination predict amyotrophic lateral sclerosis risk.

ABSTRACT:

Background

T cell infiltration around dying motor neurons is a hallmark of amyotrophic lateral sclerosis (ALS). It is not known if this immune response represents a cause or a consequence of the disease. We aimed to establish whether individual variation in regulation of a T cell driven immune response is associated with long-term ALS risk.

Methods

Tuberculin skin test (TST) following BCG vaccination represents a standardized measure of a secondary T cell driven immune response. During a Norwegian tuberculosis screening program (1963-1975) Norwegian citizens born from 1910 to 1955 underwent TST. In those previously BCG vaccinated (median 7 years prior to TST), we related tuberculin skin tests to later ALS disease identified through validated Norwegian health registers. We fi

SUBMITTER: Nakken O 

PROVIDER: S-EPMC10681879 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature