Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy.

ABSTRACT:

Introduction

Fuchs endothelial corneal dystrophy (FECD) is the leading cause of corneal blindness in developed countries. Corneal endothelial cells in FECD are susceptive to oxidative stress, leading to mitochondrial dysfunction and cell death. Oxidative stress causes many forms of cell death including parthanatos, which is characterized by translocation of apoptosis-inducing factor (AIF) to the nucleus with upregulation of poly (ADP-ribose) polymerase 1 (PARP-1) and poly (ADP-ribose) (PAR). Although cell death is an important aspect of FECD, previous reports have often analyzed immortalized cell lines, making the evaluation of cell death difficult. Therefore, we established a new in vitro FECD model to evaluate the pathophysiology of FECD.

Methods

Corneal endothelial

SUBMITTER: Sakakura S 

PROVIDER: S-EPMC10681880 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature