Early-stage non-alcoholic fatty liver disease in relation to atherosclerosis and inflammation.

ABSTRACT:

Background and aims

Non-alcoholic fatty liver disease (NAFLD) is a multisystem disease closely linked to cardiovascular disease (CVD). This study aims to investigate the connection between early-stage NAFLD and atherosclerosis, as well as the correlation between liver fibrosis and coronary heart disease while exploring underlying inflammatory mechanisms.

Methods

In this retrospective study, the authors analyzed data from 607 patients who underwent both coronary computed tomography angiography (CCTA) and abdominal ultrasonography (US). Logistic regression was utilized to examine the association between NAFLD and atherosclerosis, while mediation analysis was conducted to explore whether inflammatory markers mediate the link between liver fibrosis and coronary artery disease.

SUBMITTER: Tan SH 

PROVIDER: S-EPMC10681951 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature