Neuropathological features of levodopa-responsive parkinsonism in multiple system atrophy: an autopsy case report and comparative neuropathological study.

ABSTRACT:

Background

In typical patients with multiple system atrophy with predominant parkinsonism (MSA-P) levodopa is ineffective. However, there are some of these patients who respond well to levodopa treatment. Levodopa efficacy in MSA-P patients is thought to be related to the degree of putaminal damage, but the pathological causation between the putaminal involvement and levodopa efficacy has not been established in detail.

Objective

This study aimed to evaluate the neuropathological features of the nigrostriatal dopaminergic system in a "levodopa-responsive" MSA-P patient in comparison with "levodopa-unresponsive" conventional MSA-P patients.

Materials and methods

Clinicopathological findings were assessed in a 53-year-old Japanese man with MSA who presented with asymmet

SUBMITTER: Tamura M 

PROVIDER: S-EPMC10682068 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature