Construction of multifunctional coating with cationic amino acid-coupled peptides for osseointegration of implants.

ABSTRACT: Osseointegration is an important indicator of implant success. This process can be improved by coating modified bioactive molecules with multiple functions on the surface of implants. Herein, a simple multifunctional coating that could effectively improve osseointegration was prepared through layer-by-layer self-assembly of cationic amino acids and tannic acid (TA), a negatively charged molecule. Osteogenic growth peptide (OGP) and the arginine-glycine-aspartic acid (RGD) functional polypeptides were coupled with Lys₆ (K₆), the two polypeptides then self-assembled with TA layer by layer to form a composite film, (TA-OGP@RGD)n. The surface morphology and biomechanical properties of the coating were analyzed in gas and liquid phases, and the deposition process and kinet

SUBMITTER: Zhao B 

PROVIDER: S-EPMC10682118 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature