Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis.

ABSTRACT:

Background

Vascular adhesion protein-1 (VAP-1) is an adhesion molecule and primary amine oxidase, and Gallium-68-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetra-acetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([⁶⁸Ga]Ga-DOTA-Siglec-9) is a positron emission tomography (PET) tracer targeting VAP-1. We evaluated the feasibility of PET imaging with [⁶⁸Ga]Ga-DOTA-Siglec-9 for the detection of myocardial lesions in rats with autoimmune myocarditis.

Methods

Rats (n = 9) were immunized twice with porcine cardiac myosin in complete Freund's adjuvant. Control rats (n = 6) were injected with Freund's adjuvant alone. On day 21, in vivo PET/computed tomography (CT) imaging with [⁶⁸Ga]Ga-DOTA-Siglec-

SUBMITTER: Jahandideh A 

PROVIDER: S-EPMC10682147 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature